Kinin (av eng. quinine) er et legemiddel fremstilt av kinabark (Cinchonae cortex), bark fra kinatre (Cinchonae pubescens), og var tidligere det mest brukte middelet mot tropesykdommen malaria. I Europa gikk kinabark under beskrivelsen peruansk bark p\u00e5 1700-tallet, der den nederlandske legen Gerardi van Swieten (1700\u20131772) refererte til bruk av den i sitt seks binds legeverk publisert i 1745. Van Swieten er siden kjent som den som f\u00f8rst beskrev et tilfelle av episodisk klasehodepine.<\/p>\n
Kinin finnes blant annet i tonic og blir derfor mye brukt i cocktailen gin og tonic. Denne drinken skal ha blitt oppfunnet nettopp p\u00e5 grunn av kininet. Britiske embetsmenn i India trengte \u00e5 f\u00e5 i seg kinin og ble derfor oppfordret til \u00e5 drikke Tonic Water. Men ettersom den tidlige versjonen av Tonic Water ikke smakte spesielt godt \u2013 det var mer medisin enn leskedrikk \u2013 fant de ut at det gikk langt bedre \u00e5 f\u00e5 det i seg dersom de blandet det med gin.<\/p>\n Kort fra Wikipedia om chloroquine<\/a>:<\/p>\n Chloroquine<\/strong> was discovered in 1934 by Hans Andersag. It is on the World Health Organization’s List of Essential Medicines, the safest and most effective medicines needed in a health system. It is available as a generic medication. The wholesale cost in the developing world is about US$0.04. In the United States, it costs about US$5.30 per dose.<\/p>\n …<\/p>\n Preliminary results from a trial suggested that chloroquine is effective and safe in COVID-19 pneumonia, «improving lung imaging findings, promoting a virus-negative conversion, and shortening the disease course.»<\/p>\n Fra S\u00f8r-Korea og Kina dukker i disse dager opp ny og publisert forskning om effekten medisinen har p\u00e5 covid 19-viruset, b\u00e5de behandlende og forebyggende effekter p\u00e5st\u00e5s dokumentert. Nettsiden som har satt dette best i system er WUWT (Wattsupwiththat), som nok er mer kjent for \u00e5 publisere klimastoff enn medisinsk forskning. Jeg siterer litt derfra, kommenterer litt i tillegg, og legger ut alle relevante lenker til forskningen om effekten av chloroquine.<\/p>\n Publikasjon i Nature, (4. februar 2020), Manli Wang m.fl.<\/a><\/p>\n Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro<\/strong><\/p>\n Chloroquine, a widely-used anti-malarial and autoimmune disease drug, has recently been reported as a potential broad-spectrum antiviral drug.8,9 Chloroquine is known to block virus infection by increasing endosomal pH required for virus\/cell fusion, as well as interfering with the glycosylation of cellular receptors of SARS-CoV.10 Our time-of-addition assay demonstrated that chloroquine functioned at both entry, and at post-entry stages of the 2019-nCoV infection in Vero E6 cells (Fig. 1c, d). Besides its antiviral activity, chloroquine has an immune-modulating activity, which may synergistically enhance its antiviral effect in vivo. Chloroquine is widely distributed in the whole body, including lung, after oral administration. The EC90 value of chloroquine against the 2019-nCoV in Vero E6 cells was 6.90\u2009\u03bcM, which can be clinically achievable as demonstrated in the plasma of rheumatoid arthritis patients who received 500\u2009mg administration.11 Chloroquine is a cheap and a safe drug that has been used for more than 70 years and, therefore, it is potentially clinically applicable against the 2019-nCoV.<\/p>\n Our findings reveal that remdesivir and chloroquine are highly effective in the control of 2019-nCoV infection in vitro. Since these compounds have been used in human patients with a safety track record and shown to be effective against various ailments, we suggest that they should be assessed in human patients suffering from the novel coronavirus disease.<\/p>\n Fra US CDC<\/strong><\/p>\n Chloroquine as a prophylactic (preventative) measure against COVID-19<\/strong><\/p>\n According to research by the US CDC, chloroquine has strong antiviral effects on SARS coronavirus, both prophylactically and therapeutically. SARS coronavirus has significant similarities to COVID-19. Specifically, the CDC research was completed in primate cells using chloroquine\u2019s well known function of elevating endosomal pH. The results show that \u201cWe have identified chloroquine as an effective antiviral agent for SARS-CoV in cell culture conditions, as evidenced by its inhibitory effect when the drug was added prior to infection or after the initiation and establishment of infection. The fact that chloroquine exerts an antiviral effect during pre- and post-infection conditions suggest that it is likely to have both prophylactic and therapeutic advantages.\u201d<\/p>\n China prioritizes internal use of Active Pharmaceutical Ingredients (APIs) including Chloroquine[14]<\/p>\n In early February, Chongqing Kangle Pharmaceutical was requested by the Ministry of Industry and Information Technology, Consumption Division to promptly increase the manufacturing and production of the active pharmaceutical ingredients chloroquine phosphate despite slowed production during the Chinese New Year.<\/p>\n \u2026<\/p>\n Conclusion<\/p>\n Chloroquine can both both prevent and treat malaria. Chloroquine can prevent and treat coronavirus in primate cells (Figure 1 and Figure 2). According to South Korean and China human treatment guidelines, chloroquine is effective in treating COVID-19. Given chloroquine\u2019s human safety profile and existence, it can be implemented today in the U.S., Europe and the rest of the world. Medical doctors may be reluctant to prescribe chloroquine to treat COVID-19 since it is not FDA approved for this use. The United States of America and other countries should immediately authorize and indemnify medical doctors for prescribing chloroquine to treat COVID-19.<\/p>\n En annen s\u00e5kalt klimaskeptiker, dr. Roy Spencer<\/a>, fant forskning om temaet i tittelen over. Det kan virkelig se ut som om land der man forebygger malaria med egnet medisin, ikke er s\u00e6rlig utsatt for coronaviruset n\u00e5 i dag. Og motsatt. De nasjonene som n\u00e5 opplever spredning av coronaviruset, er ikke plaget av malaria, og har derfor ikke noe forebyggende system satt i verk. N\u00e5r mennesker ikke har f\u00e5tt malariaforebyggende- eller behandlende medisin, er de mer utsatt for coronaviruset. Han henviser til forskning om dette, og dere kan lese selv. Jeg tar bare med en illustrasjon fra forskningen.<\/p>\n Hva alt dette betyr? Det betyr at en gammel malariamedisin har b\u00e5de helbredende og forebyggende effekt p\u00e5 coronaviruset. Hvor velfungerende det er, vil historien fortelle oss mer om. Jeg kan ikke stort mer om medisin enn at jeg vet at det som oftest smaker vondt, s\u00e5 jeg kan ikke konkludere p\u00e5 annet vis enn dette:<\/p>\n To gamle drikkekompiser diskuterte mulige negative helseeffekter av alkohol. Den ene spurte: – Tror du vi kommer til \u00e5 bli s\u00e6rlig eldre, vi som stort sett har v\u00e6rt drita fulle i 40 \u00e5r? Hvorp\u00e5 svirebroren svarte: – Den som har lever f\u00e5r se.<\/p>\n Framhevet bilde fra Store Norske Medisinske leksikon: \u00d8ye, Ivar. (2018, 22. november). kinin. I Store medisinske leksikon. Hentet\u00a020. mars 2020<\/span>\u00a0fra https:\/\/sml.snl.no\/kinin<\/p>\n","protected":false},"excerpt":{"rendered":" I g\u00e5r, den 19. mars, gikk Donald Trump ut og fortalte at de hadde funnet botemiddelet mot coronaviruset. Det var ikke en ny medisin, eller en nyprodusert vaksine som ville gitt milliarder til en aldeles korrupt legemiddelindustri. Neida, medisinen er en god gammel malariamedisin, chloroquine. Medisinen kan v\u00e6re b\u00e5de helbredende og forebyggende.<\/p>\n Malariamedisinen Chloroquine<\/p>\n![\"\"](\"https:\/\/www.jostemikk.com\/wp-content\/uploads\/2020\/03\/Gin-Tonic-med-kinin-i-tonic-vannet.jpg\")
<\/a>Om chloroquine p\u00e5 US Centers for Disease Control and Prevention og i Nature<\/h4>\n
Ikke malaria i landene med coronavirus-spredning og ikke corona i malariaplagede land<\/h4>\n
![\"\"](\"https:\/\/www.jostemikk.com\/wp-content\/uploads\/2020\/03\/Corona-og-malaria.jpg\")
<\/a>Konklusjon<\/h4>\n